Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 3.672


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_757454800.831.2e-02Click!
JUNDchr19_-_18392436-0.724.2e-02Click!
FOSL1chr11_-_656678090.502.1e-01Click!
FOSBchr19_+_45971249-0.403.3e-01Click!
JUNBchr19_+_129022950.196.6e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_21452981 25.467 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_183155173 17.394 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_153003677 14.830 NM_003125
SPRR1B
small proline-rich protein 1B
chr1_+_183155361 14.685 LAMC2
laminin, gamma 2
chr1_+_183155393 13.402 LAMC2
laminin, gamma 2
chr3_-_151034514 12.904 NM_023915
GPR87
G protein-coupled receptor 87
chr20_+_44637539 11.044 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr12_-_52886971 10.117 NM_005554
KRT6A
keratin 6A
chr19_-_51523272 9.993 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr15_+_40532034 8.798 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_+_47666288 8.531 NM_153838
GPR115
G protein-coupled receptor 115
chr18_+_61442611 8.255 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr11_+_394199 8.192 NM_007183
PKP3
plakophilin 3
chr11_+_394238 7.886 PKP3
plakophilin 3
chr2_+_47596447 7.832 EPCAM
epithelial cell adhesion molecule
chr11_-_118134986 7.778 MPZL2
myelin protein zero-like 2
chr18_+_61554938 7.666 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr11_-_118134956 7.579 MPZL2
myelin protein zero-like 2
chr10_+_118187381 7.360 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr7_+_73245192 7.304 NM_001305
CLDN4
claudin 4
chr14_-_94854910 7.228 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_-_39768939 7.160 NM_005557
KRT16
keratin 16
chr19_-_36004553 7.052 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr1_-_207205996 7.045 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr1_+_35220647 7.039 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr19_-_35992798 6.953 NM_001035516
DMKN
dermokine
chr17_-_39675078 6.891 NM_002275
KRT15
keratin 15
chr11_-_118135197 6.720 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr14_-_94855120 6.473 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94849552 6.385 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_-_53343607 6.347 KRT8
keratin 8
chr15_+_41136178 6.048 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr19_-_39264144 5.942 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr7_+_26400503 5.931 NM_001199837
SNX10
sorting nexin 10
chr1_+_15256295 5.801 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr1_-_209824641 5.644 NM_001017402
LAMB3
laminin, beta 3
chr5_+_145317297 5.580 SH3RF2
SH3 domain containing ring finger 2
chr7_+_26331611 5.483 SNX10
sorting nexin 10
chr16_+_57662301 5.452 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_+_152956563 5.331 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr15_+_41136622 5.191 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr15_+_40531236 5.066 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_35246789 5.004 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr10_+_24755459 4.853 KIAA1217
KIAA1217
chr4_-_123542165 4.809 NM_001207006
NM_021803
IL21

interleukin 21

chr1_+_44398991 4.703 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr17_-_8021806 4.595 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr18_+_55888838 4.508 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_-_102668822 4.475 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_102668892 4.352 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr18_+_55888799 4.312 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_-_88730928 4.265 LOC100133190
uncharacterized LOC100133190
chr12_+_107974633 4.255 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr10_+_82173574 4.224 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr17_-_8022134 4.178 NM_001165960
ALOXE3
arachidonate lipoxygenase 3
chr1_+_186798031 4.069 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr8_+_120220554 3.928 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr5_+_147582338 3.860 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr1_-_153029987 3.812 NM_005988
SPRR2A
small proline-rich protein 2A
chr1_+_32043745 3.803 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_47596286 3.736 NM_002354
EPCAM
epithelial cell adhesion molecule
chr18_-_74207145 3.699 NM_014643
ZNF516
zinc finger protein 516
chr11_+_10476665 3.545 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr9_-_139948448 3.537 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chrX_-_33229428 3.520 NM_004006
DMD
dystrophin
chr1_-_153521717 3.501 NM_002960
S100A3
S100 calcium binding protein A3
chr1_-_160990862 3.478 F11R
F11 receptor
chr17_-_7493389 3.463 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr1_-_28520379 3.440 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr9_+_35673852 3.412 NM_001216
CA9
carbonic anhydrase IX
chr19_+_39279849 3.406 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr15_+_89182038 3.401 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_-_8815370 3.377 NM_003480
MFAP5
microfibrillar associated protein 5
chr1_-_153013593 3.369 NM_006945
SPRR2D
small proline-rich protein 2D
chr17_-_56494930 3.269 NM_017763
RNF43
ring finger protein 43
chr5_+_145316120 3.264 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr5_+_36608430 3.251 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_160990971 3.135 NM_016946
F11R
F11 receptor
chr1_+_152881022 3.120 NM_005547
IVL
involucrin
chr18_-_47376156 3.116 MYO5B
myosin VB
chr5_+_52776479 3.113 FST
follistatin
chr5_-_1882764 3.092 NM_016358
IRX4
iroquois homeobox 4
chr5_+_52776408 3.090 FST
follistatin
chr16_-_72206348 3.083 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr4_-_36245893 3.070 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_+_78109808 3.064 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr6_-_138428477 3.002 NM_022121
PERP
PERP, TP53 apoptosis effector
chr17_-_56494889 2.973 RNF43
ring finger protein 43
chr11_+_12308446 2.904 NM_032867
MICALCL
MICAL C-terminal like
chr6_+_30856462 2.858 NM_001202521
NM_001202522
NM_013994
DDR1


discoidin domain receptor tyrosine kinase 1


chr9_-_117111278 2.843 AKNA
AT-hook transcription factor
chr19_-_291335 2.841 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr1_+_200863948 2.834 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr12_+_56732658 2.827 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr11_+_20620945 2.826 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr1_+_152486977 2.811 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr19_-_44174497 2.773 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr11_+_62649160 2.772 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr8_+_24771276 2.737 NEFM
neurofilament, medium polypeptide
chr19_+_7953380 2.720 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr16_-_72206023 2.714 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr10_-_6019454 2.714 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr10_-_6019880 2.693 NM_001243539
IL15RA
interleukin 15 receptor, alpha
chr1_+_24645914 2.684 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr2_+_220492286 2.669 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr6_+_47624222 2.636 NM_153839
GPR111
G protein-coupled receptor 111
chr8_+_24771268 2.616 NM_005382
NEFM
neurofilament, medium polypeptide
chr1_+_24645811 2.601 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr3_-_98241357 2.595 CLDND1
claudin domain containing 1
chr6_+_13924676 2.583 NM_001165034
RNF182
ring finger protein 182
chr5_+_35856990 2.579 NM_002185
IL7R
interleukin 7 receptor
chr4_-_89080010 2.571 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr22_+_45072936 2.566 PRR5
proline rich 5 (renal)
chr19_-_51472816 2.510 NM_002774
KLK6
kallikrein-related peptidase 6
chr7_-_16844606 2.501 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr4_+_84457256 2.493 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr19_-_36019194 2.484 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr17_+_73717515 2.480 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr7_-_143105897 2.472 NM_005232
EPHA1
EPH receptor A1
chr19_-_291168 2.458 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr20_-_6104056 2.435 NM_017671
FERMT1
fermitin family member 1
chr4_+_84457390 2.432 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr12_+_56473808 2.404 NM_001982
NM_001005915
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr9_-_124990949 2.392 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr2_+_113875469 2.384 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr4_+_76481257 2.365 NM_001206981
NM_178497
C4orf26

chromosome 4 open reading frame 26

chr12_-_106533810 2.341 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr1_+_81771844 2.322 LPHN2
latrophilin 2
chr7_+_26331493 2.318 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr16_-_2908105 2.311 NM_022119
PRSS22
protease, serine, 22
chr13_-_86373328 2.309 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr17_-_39942937 2.304 NM_002230
NM_021991
JUP

junction plakoglobin

chr20_-_1309809 2.288 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr8_-_143851223 2.250 NM_177458
LYNX1
Ly6/neurotoxin 1
chr18_+_55888750 2.240 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_-_43969723 2.219 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr13_+_97794050 2.212 MBNL2
muscleblind-like 2 (Drosophila)
chr8_-_125580745 2.172 MTSS1
metastasis suppressor 1
chr14_+_96722546 2.172 NM_000710
BDKRB1
bradykinin receptor B1
chr17_+_73717556 2.167 ITGB4
integrin, beta 4
chr6_+_138188352 2.162 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_+_106546736 2.136 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr17_+_73717596 2.124 ITGB4
integrin, beta 4
chr11_-_120008801 2.072 TRIM29
tripartite motif containing 29
chr11_+_128563772 2.059 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr8_+_32504250 2.056 NM_013959
NRG1
neuregulin 1
chr6_-_13408368 2.048 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr17_-_39780762 2.045 NM_000422
KRT17
keratin 17
chr5_+_68788118 1.933 NM_002538
OCLN
occludin
chr18_+_21693316 1.924 TTC39C
tetratricopeptide repeat domain 39C
chr1_-_153067000 1.924 NM_001024209
SPRR2E
small proline-rich protein 2E
chr12_+_9142136 1.904 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr5_+_52776263 1.898 NM_006350
NM_013409
FST

follistatin

chr5_-_134914447 1.891 CXCL14
chemokine (C-X-C motif) ligand 14
chr11_+_10477480 1.869 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr5_-_134914968 1.867 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr22_+_45072687 1.863 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr19_-_44174271 1.860 PLAUR
plasminogen activator, urokinase receptor
chr1_-_156675237 1.849 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr10_-_116418056 1.827 NM_002313
ABLIM1
actin binding LIM protein 1
chr18_+_61254533 1.821 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr16_-_48266181 1.819 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr11_+_121461070 1.796 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr16_-_30124829 1.793 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr17_+_21191347 1.783 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr22_-_37584254 1.756 NM_031910
NM_182486
C1QTNF6

C1q and tumor necrosis factor related protein 6

chr11_+_128563973 1.747 FLI1
Friend leukemia virus integration 1
chr5_+_36606667 1.745 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_102651321 1.745 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chrX_-_154563735 1.726 NM_001289
CLIC2
chloride intracellular channel 2
chr1_-_6662898 1.715 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr17_-_38938785 1.712 NM_181537
KRT27
keratin 27
chr12_+_95676175 1.711 VEZT
vezatin, adherens junctions transmembrane protein
chr4_+_100737980 1.711 NM_014395
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr12_-_8219001 1.695 C3AR1
complement component 3a receptor 1
chr2_-_165697927 1.684 NM_014900
COBLL1
COBL-like 1
chr10_-_118501981 1.680 NM_025015
HSPA12A
heat shock 70kDa protein 12A
chr2_-_165697852 1.653 COBLL1
COBL-like 1
chr3_-_98241722 1.647 CLDND1
claudin domain containing 1
chr17_-_43502992 1.636 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr17_-_39743085 1.635 NM_000526
KRT14
keratin 14
chrX_-_33357725 1.600 NM_000109
DMD
dystrophin
chr1_+_89829435 1.585 NM_198460
GBP6
guanylate binding protein family, member 6
chr7_+_69063768 1.585 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr18_-_28742744 1.567 NM_004948
NM_024421
DSC1

desmocollin 1

chr5_+_150020201 1.564 NM_001109974
NM_007286
SYNPO

synaptopodin

chr12_-_8218930 1.541 NM_004054
C3AR1
complement component 3a receptor 1
chr19_+_6464259 1.540 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr7_-_36429695 1.486 NM_001100425
KIAA0895
KIAA0895
chr6_+_121756744 1.480 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr1_-_43751238 1.471 NM_182517
NM_001164829
C1orf210

chromosome 1 open reading frame 210

chr19_-_51512803 1.469 NM_012315
KLK9
kallikrein-related peptidase 9
chr1_+_24649529 1.465 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr20_+_9288446 1.462 NM_000933
PLCB4
phospholipase C, beta 4
chr7_+_48128225 1.460 NM_181597
UPP1
uridine phosphorylase 1
chr1_-_9970265 1.429 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr1_+_247579457 1.429 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr1_+_27189628 1.413 NM_006142
SFN
stratifin
chr21_+_43619798 1.408 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr6_-_44233499 1.400 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 5.01e-05 GO:0007165 signal transduction
1.32 1.18e-04 GO:0023052 signaling
2.61 6.20e-04 GO:0008544 epidermis development
1.27 1.41e-03 GO:0051716 cellular response to stimulus
1.17 1.99e-03 GO:0065007 biological regulation
1.18 3.23e-03 GO:0050794 regulation of cellular process
1.17 5.48e-03 GO:0050789 regulation of biological process
1.27 1.10e-02 GO:0032502 developmental process
1.19 1.23e-02 GO:0050896 response to stimulus
1.47 2.18e-02 GO:0035556 intracellular signal transduction
1.29 2.26e-02 GO:0048856 anatomical structure development
1.31 2.27e-02 GO:0048731 system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.25 1.63e-03 GO:0001533 cornified envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.52 2.18e-02 GO:0030234 enzyme regulator activity